Article
HLA class I associations with rates of HIV-1 seroconversion and disease progression in the Pumwani Sex Worker Cohort.
Tissue antigens - 1 Feb 2013
Peterson T A, Kimani J, Wachihi C, Bielawny T, Mendoza L, Thavaneswaran S, Narayansingh M J, Kariri T, Liang B, Ball T B, Ngugi E N, Plummer F A, Luo M
Abstract excerpt
Class I human leukocyte antigens (HLA) play an important role in the adaptive immune response by presenting antigens to CD8+ T cells. Studies have reported that several HLA class I alleles are associated with differential disease progression in human immunodeficiency virus (HIV)-infected individuals, however, few class I associations with resistance or susceptibility to HIV-1 infection have been reported. We...
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