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Article

Early evolution of human leucocyte antigen-associated escape mutations in variable Gag proteins predicts CD4+ decline in HIV-1 subtype C-infected women.

AIDS (London, England) - 14 Jan 2017

Chopera Denis R, Ntale Roman, Ndabambi Nonkululeko, Garrett Nigel, Gray Clive M, Matten David, Abdool Karim Quarraisha, Abdool Karim Salim, Williamson Carolyn

Abstract excerpt

OBJECTIVE: HIV-1 escape from cytotoxic T-lymphocytes results in the accumulation of human leucocyte antigen (HLA)-associated mutations in the viral genome. To understand the contribution of early escape to disease progression, this study investigated the evolution and pathogenic implications of cytotoxic T-lymphocyte escape in a cohort followed from infection for 5 years. METHODS: Viral loads and CD4 cell counts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27755110
DOI: 10.1097/QAD.0000000000001298
PMCID: PMC5177455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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