Article
Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients.
The Journal of experimental medicine - 13 Apr 2009
Crawford Hayley, Lumm Wendy, Leslie Alasdair, Schaefer Malinda, Boeras Debrah, Prado Julia G, Tang Jianming, Farmer Paul, Ndung'u Thumbi, Lakhi Shabir, Gilmour Jill, Goepfert Paul, Walker Bruce D, Kaslow Richard, Mulenga Joseph, Allen Susan, Goulder Philip J R, Hunter Eric
Abstract excerpt
HLA-B*57 is the class I allele most consistently associated with control of human immunodeficiency virus (HIV) replication, which may be linked to the specific HIV peptides that this allele presents to cytotoxic T lymphocytes (CTLs), and the resulting efficacy of these cellular immune responses. In two HIV C clade-infected populations in South Africa and Zambia, we sought to elucidate the role of HLA-B*5703 in...
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