Article
Viral replication capacity as a correlate of HLA B57/B5801-associated nonprogressive HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2007
Navis Marjon, Schellens Ingrid, van Baarle Debbie, Borghans José, van Swieten Peter, Miedema Frank, Kootstra Neeltje, Schuitemaker Hanneke
Abstract excerpt
HLA B57 and the closely related HLA B5801 are over-represented among HIV-1 infected long-term nonprogressors (LTNPs). It has been suggested that this association between HLA B57/5801 and asymptomatic survival is a consequence of strong CTL responses against epitopes in the viral Gag protein. Moreover, CTL escape mutations in Gag would coincide with viral attenuation, resulting in low viral load despite evasion...
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