Article
Virological and immunological factors associated with HIV-1 differential disease progression in HLA-B 58:01-positive individuals.
Journal of virology - 1 Jul 2011
Chopera D R, Mlotshwa M, Woodman Z, Mlisana K, de Assis Rosa D, Martin D P, Abdool Karim S, Gray C M, Williamson C
Abstract excerpt
Molecular epidemiology studies have identified HLA-B 58:01 as a protective HIV allele. However, not all B 58:01-expressing persons exhibit slow HIV disease progression. We followed six HLA-B 58:01-positive, HIV subtype C-infected individuals for up to 31 months from the onset of infection and observed substantial variability in their clinical progression despite comparable total breadths of T cell responses. We...
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