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Article

Association of MHC-I genotypes with disease progression in HIV/SIV infections

1 Jan 2012

Abstract excerpt

Virus-specific cytotoxic T lymphocytes (CTLs) are major effectors in acquired immune responses against viral infection. Virus-specific CTLs recognize specific viral peptides presented by major histocompatibility complex class-I (MHC-I) on the surface of virus-infected target cells via their T cell receptor (TCR) and eliminate target cells by both direct and indirect mechanisms. In human immunodeficiency virus...

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Identifiers

PMID: 22754552
DOI: 10.3389/fmicb.2012.00234

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