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Article

Virus-specific CD8+ T-cell responses better define HIV disease progression than HLA genotype.

Journal of virology - 1 May 2010

Dinges Warren L, Richardt Julia, Friedrich David, Jalbert Emilie, Liu Yi, Stevens Claire E, Maenza Janine, Collier Ann C, Geraghty Daniel E, Smith Jeremy, Moodie Zoe, Mullins James I, McElrath M Juliana, Horton Helen

Abstract excerpt

HLA alleles B57/58, B27, and B35 have the strongest genetic associations with HIV-1 disease progression. The mechanisms of these relationships may be host control of HIV-1 infection via CD8(+) T-cell responses. We examined these immune responses in subjects from the Seattle Primary Infection Cohort with these alleles. CD8(+) T-cell responses to conserved HIV epitopes within B57/58 alleles (TW10 and KF11) and B27...

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Share to CD4 Lymphocyte Count
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20147397
DOI: 10.1128/JVI.02438-09
PMCID: PMC2863751

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