Article
HIV evolution: CTL escape mutation and reversion after transmission.
Nature medicine - 1 Mar 2004
Leslie A J, Pfafferott K J, Chetty P, Draenert R, Addo M M, Feeney M, Tang Y, Holmes E C, Allen T, Prado J G, Altfeld M, Brander C, Dixon C, Ramduth D, Jeena P, Thomas S A, St John A, Roach T A, Kupfer B, Luzzi G, Edwards A, Taylor G, Lyall H, Tudor-Williams G, Novelli V, Martinez-Picado J, Kiepiela P, Walker B D, Goulder P J R
Abstract excerpt
Within-patient HIV evolution reflects the strong selection pressure driving viral escape from cytotoxic T-lymphocyte (CTL) recognition. Whether this intrapatient accumulation of escape mutations translates into HIV evolution at the population level has not been evaluated. We studied over 300 patients drawn from the B- and C-clade epidemics, focusing on human leukocyte antigen (HLA) alleles HLA-B57 and HLA-B5801,...
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