Article
Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases.
Cancer research - 15 Oct 2008
Barault Ludovic, Charon-Barra Céline, Jooste Valérie, de la Vega Mathilde Funes, Martin Laurent, Roignot Patrick, Rat Patrick, Bouvier Anne-Marie, Laurent-Puig Pierre, Faivre Jean, Chapusot Caroline, Piard Francoise
Abstract excerpt
The CpG island methylator phenotype (CIMP) is a distinct phenotype in colorectal cancer, associated with specific clinical, pathologic, and molecular features. However, most of the studies stratified methylation according to two subgroups (CIMP-High versus No-CIMP/CIMP-Low). In our study, we defi...
Topics
- Adenocarcinoma
- Adult
- Aged
- Colonic Neoplasms
- CpG Islands
- DNA Methylation
- Female
- Humans
- Male
- Microsatellite Instability
- Middle Aged
- Mutation
- Phenotype
- Prognosis
- Proto-Oncogene Proteins