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Article

The CpG island methylator phenotype correlates with long-range epigenetic silencing in colorectal cancer.

Molecular cancer research : MCR - 1 Apr 2008

Karpinski Pawel, Ramsey David, Grzebieniak Zygmunt, Sasiadek Maria M, Blin Nikolaus

Abstract excerpt

The CpG island methylator phenotype (CIMP), characterized by an exceptionally high frequency of methylation of discrete CpG islands, is observed in 18% to 25% of sporadic colorectal cancers. Another hypermethylation pattern found in colorectal cancers, termed long-range epigenetic silencing, is a...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Neoplasm

Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 18403637
DOI: 10.1158/1541-7786.MCR-07-2158

Genes

INHBB
SCTR
BRAF
MLH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18403637-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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