Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of new function through a single amino acid change in the yeast repressor Sum1p.

Molecular and cellular biology - 1 Apr 2008

Safi Alexias, Wallace Kelley A, Rusche Laura N

Abstract excerpt

The SUM1-1 mutation is an example of a single amino acid change that results in new function. Wild-type Sum1p in Saccharomyces cerevisiae is a DNA-binding repressor that acts locally, whereas mutant Sum1-1p forms an extended repressive chromatin structure. By characterizing a panel of mutations in which various amino acids replaced the critical residue, threonine 988, we found that threonine was required for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to DNA, Fungal
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Nuclear Proteins

Share to Replication Origin

Share to Repressor Proteins

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18268008
DOI: 10.1128/MCB.01785-07
PMCID: PMC2293110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of new function through a single amino acid change in the yeast repressor Sum1p.PMID 18268008Read ↗

Sum1p, the origin recognition complex, and the spreading of a promoter-specific repressor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Analyses of SUM1-1-mediated long-range repression.Semantic proximity Read ↗

The duplicated deacetylases Sir2 and Hst1 subfunctionalized by acquiring complementary inactivating mutations.Semantic proximity Read ↗

Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1.Semantic proximity Read ↗

Mutational effects and the evolution of new protein functions.Semantic proximity Read ↗

The evolution of human SIRT1 for multi-specificity is enabled by active-site adaptationSemantic proximity Read ↗

Mistranslating tRNA identifies a deleterious S213P mutation in the Saccharomyces cerevisiaeeco1-1 allele.Semantic proximity Read ↗

Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes.Semantic proximity Read ↗

Mistranslating tRNA identifies a deleterious S213P mutation in the <i>Saccharomyces cerevisiae eco1-1</i> alleleSemantic proximity Read ↗

Cha4p of Saccharomyces cerevisiae activates transcription via serine/threonine response elements.Semantic proximity Read ↗

SUM1-1: a suppressor of silencing defects in Saccharomyces cerevisiae.Semantic proximity Read ↗

Catalytic-site mutations in the MYST family histone Acetyltransferase Esa1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.