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Article

Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1.

PloS one - 1 Jan 2013

Williamson Kelly, Schneider Victoria, Jordan Rachel A, Mueller John E, Henderson Pozzi Michelle, Bryk Mary

Abstract excerpt

In S. cerevisiae, the lysine methyltransferase Set1 is a member of the multiprotein complex COMPASS. Set1 catalyzes mono-, di- and trimethylation of the fourth residue, lysine 4, of histone H3 using methyl groups from S-adenosylmethionine, and requires a subset of COMPASS proteins for this activity. The methylation activity of COMPASS regulates gene expression and chromosome segregation in vivo. To improve...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23469257
DOI: 10.1371/journal.pone.0057974
PMCID: PMC3585878

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1.PMID 23469257Read ↗

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation.Semantic proximity Read ↗

Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism.Semantic proximity Read ↗

The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation.Semantic proximity Read ↗

Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.Semantic proximity Read ↗

Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3.Semantic proximity Read ↗

Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains.Semantic proximity Read ↗

COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.Semantic proximity Read ↗

Feedback control of Set1 protein levels is important for proper H3K4 methylation patterns.Semantic proximity Read ↗

Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA replication origin function is promoted by H3K4 di-methylation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Histone acetyltransferase Gcn5 regulates gene expression by promoting the transcription of histone methyltransferase SET1.Semantic proximity Read ↗

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