Article
Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1.
PloS one - 1 Jan 2013
Williamson Kelly, Schneider Victoria, Jordan Rachel A, Mueller John E, Henderson Pozzi Michelle, Bryk Mary
Abstract excerpt
In S. cerevisiae, the lysine methyltransferase Set1 is a member of the multiprotein complex COMPASS. Set1 catalyzes mono-, di- and trimethylation of the fourth residue, lysine 4, of histone H3 using methyl groups from S-adenosylmethionine, and requires a subset of COMPASS proteins for this activi...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Catalytic Domain
- Cell Cycle Proteins
- Conserved Sequence
- DNA, Ribosomal
- Gene Expression Regulation, Fungal
- Gene Silencing
- Histone-Lysine N-Methyltransferase
- Histones
- Kinetochores
- Lysine
- Microtubule-Associated Proteins