Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational effects and the evolution of new protein functions.

Nature reviews. Genetics - 1 Aug 2010

Soskine Misha, Tawfik Dan S

Abstract excerpt

The divergence of new genes and proteins occurs through mutations that modulate protein function. However, mutations are pleiotropic and can have different effects on organismal fitness depending on the environment, as well as opposite effects on protein function and dosage. We review the pleiotr...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Proteins
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Duplication

Share to Genetic Variation

Share to Models, Genetic

Share to Selection, Genetic

Source

Identifiers

PMID: 20634811
DOI: 10.1038/nrg2808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20634811-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational effects and the evolution of new protein functions.PMID 20634811Read ↗

Causes of molecular convergence and parallelism in protein evolution.Semantic proximity Read ↗

Molecular evolution in light of regulatory-coding epistasis.Semantic proximity Read ↗

New genes as drivers of phenotypic evolution.Semantic proximity Read ↗

Causes and evolutionary significance of genetic convergence.Semantic proximity Read ↗

Determining the factors driving selective effects of new nonsynonymous mutations.Semantic proximity Read ↗

Evolutionary framework for protein sequence evolution and gene pleiotropy.Semantic proximity Read ↗

Genomic and structural aspects of protein evolution.Semantic proximity Read ↗

New gene evolution: little did we know.Semantic proximity Read ↗

Epistasis in protein evolution.Semantic proximity Read ↗

Gene functional trade-offs and the evolution of pleiotropy.Semantic proximity Read ↗

Scaling of mutational effects in models for pleiotropy.Semantic proximity Read ↗

The distribution of fitness effects of new mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.