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Article

Catalytic-site mutations in the MYST family histone Acetyltransferase Esa1.

Genetics - 1 Mar 2008

Decker Peter V, Yu David Y, Iizuka Masayoshi, Qiu Qifeng, Smith M Mitchell

Abstract excerpt

Esa1 is the only essential histone acetyltransferase (HAT) in budding yeast. It is the catalytic subunit of at least two multiprotein complexes, NuA4 and Piccolo NuA4 (picNuA4), and its essential function is believed to be its catalytic HAT activity. To examine the role of Esa1 in DNA damage repair, we isolated viable esa1 mutants with a range of hypersensitivities to the toposide camptothecin. Here we show that...

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Identifiers

PMID: 18245364
DOI: 10.1534/genetics.107.080135
PMCID: PMC2278108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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