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Article

Sum1p, the origin recognition complex, and the spreading of a promoter-specific repressor in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jul 2005

Lynch Patrick J, Fraser Hunter B, Sevastopoulos Elena, Rine Jasper, Rusche Laura N

Abstract excerpt

In Saccharomyces cerevisiae, Sum1p is a promoter-specific repressor. A single amino acid change generates the mutant Sum1-1p, which causes regional silencing at new loci where wild-type Sum1p does not act. Thus, Sum1-1p is a model for understanding how the spreading of repressive chromatin is regulated. When wild-type Sum1p was targeted to a locus where mutant Sum1-1p spreads, wild-type Sum1p did not spread as...

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Identifiers

PMID: 15988008
DOI: 10.1128/MCB.25.14.5920-5932.2005
PMCID: PMC1168811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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