Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The duplicated deacetylases Sir2 and Hst1 subfunctionalized by acquiring complementary inactivating mutations.

Molecular and cellular biology - 1 Aug 2011

Froyd Cara A, Rusche Laura N

Abstract excerpt

Protein families are generated by successive rounds of gene duplication and subsequent diversification. However, the paths by which duplicated genes acquire distinct functions are not well characterized. We focused on a pair of duplicated deacetylases from Saccharomyces cerevisiae, Sir2 and Hst1, that subfunctionalized after duplication. As a proxy for the ancestral, nonduplicated deacetylase, we studied Sir2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to Kluyveromyces
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Interaction Domains and Motifs

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

Share to Sirtuin 2

Source

Open in PubMed Open full text

Identifiers

PMID: 21690292
DOI: 10.1128/MCB.05175-11
PMCID: PMC3147794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The duplicated deacetylases Sir2 and Hst1 subfunctionalized by acquiring complementary inactivating mutations.PMID 21690292Read ↗

Sporadic Gene Loss After Duplication Is Associated with Functional Divergence of Sirtuin Deacetylases Among Candida Yeast Species.Semantic proximity Read ↗

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.Semantic proximity Read ↗

Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.Semantic proximity Read ↗

Diversity in the Sir2 family of protein deacetylasesSemantic proximity Read ↗

HST1 increases replicative lifespan of a sir2Δ mutant in the absence of PDE2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sum1p, the origin recognition complex, and the spreading of a promoter-specific repressor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Alternative splicing and subfunctionalization generates functional diversity in fungal proteomes.Semantic proximity Read ↗

Evolution of new function through a single amino acid change in the yeast repressor Sum1p.Semantic proximity Read ↗

The RSC (Remodels the Structure of Chromatin) complex of Candida albicans shows compositional divergence with distinct roles in regulating pathogenic traitsSemantic proximity Read ↗

HST1, a new member of the SIR2 family of genes.Semantic proximity Read ↗

Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains.Semantic proximity Read ↗

The conserved core of a human SIR2 homologue functions in yeast silencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.