Article

The evolution of human SIRT1 for multi-specificity is enabled by active-site adaptation

2020-01-14

Abstract excerpt

Many enzymes that catalyze protein post - translational modifications (PTM) can specifically modify multiple target proteins. However, little is known regarding the molecular basis and evolution of multi-specificity in these enzymes. Here, we used bioinformatics and experimental approaches to investigate the molecular basis and evolution of multi-specificity in the sirtuin-1 (SIRT1) deacetylase. Guided by bioinfo...

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Literature Corpus work: 5839955e-42e2-59f6-88d3-a1cd1a113a16
DOI: 10.1101/2020.01.12.903153

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