Article

Endogenous oncogenic KRAS expression increases cell proliferation and motility in near-diploid hTERT RPE-1 cells

2023-09-08

Abstract excerpt

About 18% of all human cancers carry a mutation in the KRAS gene making it among the most sought-after anti-cancer targets. However, mutant KRas protein has proved remarkably undruggable. The recent approval of the first generation of RAS inhibitors therefore marks a seminal milestone in the history of cancer research. Inevitably though, it also raises the predictable challenges of limited drug efficacies and acq...

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Literature Corpus work: 13836850-b7b2-53a9-962e-0be4bc3cbe8f
DOI: 10.1101/2023.09.08.556827

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