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Article

Involvement of Ras in extraembryonic endoderm differentiation of embryonic stem cells.

Biochemical and biophysical research communications - 16 Jan 2004

Yoshida-Koide Urara, Matsuda Takahiko, Saikawa Kunikazu, Nakanuma Yasuni, Yokota Takashi, Asashima Makoto, Koide Hiroshi

Abstract excerpt

Embryonic stem (ES) cells, derived from the inner cell mass of blastocyst can differentiate into multiple cell lineages. In this study, we examined the possible involvement of Ras in ES cell differentiation. We found that Ras was activated upon formation of embryoid bodies (EBs), an initial step in ES cell differentiation. When expressed during EB differentiation, a dominant-negative mutant of Ras suppressed...

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PMID: 14697213
DOI: 10.1016/j.bbrc.2003.11.138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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