Article
Endogenous oncogenic KRAS expression increases cell proliferation and motility in near-diploid hTERT RPE-1 cells.
The Journal of biological chemistry - 1 Jun 2024
Hindul Naushin L, Abbott Lauren R, Adan Sumaya M D, Straatman Kornelis R, Fry Andrew M, Hirota Kouji, Tanaka Kayoko
Abstract excerpt
About 18% of all human cancers carry a mutation in the KRAS gene making it among the most sought-after anticancer targets. However, mutant KRas protein has proved remarkably undruggable. The recent approval of the first generation of RAS inhibitors therefore marks a seminal milestone in the history of cancer research. It also raises the predictable challenges of limited drug efficacies and acquired resistance....
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