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Article

Isoform-Specific Ras Functions in Development and Cancer

26 Feb 2009

Abstract excerpt

The three closely related mammalian ras genes, Hras, Nras and Kras, have each been implicated in human tumorigenesis by virtue of mutational activation. However, while these genes encode proteins with very similar biochemical properties, activating ras alleles corresponding to the various isoforms have been linked to particular malignancies. Accumulating evidence suggests that these proteins exert distinct...

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PMID: 19243303
DOI: 10.2217/14796694.5.1.105

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