Article

RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation

2023-10-06

Abstract excerpt

The Ras-MAPK pathway is aberrantly regulated in cancer and developmental diseases called RASopathies. While typically the impact of Ras on the proliferation of various cancer cell lines is assessed, it is poorly established how Ras affects cellular differentiation. Here we implement the C2C12 myoblast cell line to systematically study the effect of Ras mutants and Ras-pathway drugs on differentiation. We first pro...

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Literature Corpus work: 3232388b-442b-5b9e-a8e5-a88f40ebf061
DOI: 10.1101/2023.10.05.561021

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