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A perspective on the early days of RAS research

29 Jul 2020

Abstract excerpt

The name of the oncogene, ras, has its origin in studies of murine leukemia viruses in the 1960s by Jenny Harvey (H-ras) and by Werner Kirsten (K-ras) which, at high doses, produced sarcomas in rats. Transforming retroviruses were isolated, and its oncogene was named ras after rat sarcoma. From 1979, cellular ras sequences with transforming properties were identified by transfection of tumor DNA initially by...

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PMID: 32728828
DOI: 10.1007/s10555-020-09919-1

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