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Article

Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility.

Developmental biology - 15 Mar 2008

Takatsuka Atsuko, Yagi Reiko, Koike Masato, Oneyama Chitose, Nada Shigeyuki, Schmedt Christian, Uchiyama Yasuo, Okada Masato

Abstract excerpt

Src family kinases (SFKs) have been implicated in the regulation of cell motility. To verify their in vivo roles during development, we generated mutant mice in which Csk, a negative regulator of SFKs, was inactivated in neural crest lineages using the Protein zero promoter in a Cre-loxP system. Inactivation of Csk caused deformities in various tissues of neural crest origins, including facial dysplasia and...

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Source

Identifiers

PMID: 18262517
DOI: 10.1016/j.ydbio.2008.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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