Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p130(Cas), an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblasts.

Biochemical and biophysical research communications - 19 Aug 1999

Honda H, Nakamoto T, Sakai R, Hirai H

Abstract excerpt

p130(Cas) (Cas) is an adaptor molecule which becomes tyrosine phosphorylated by v-Src- or v-Crk-triggered transformation and several physiological stimuli, such as cell attachment to fibronectin. We previously generated mice lacking Cas and demonstrated that Cas functions as an assembling molecule of actin filaments. To further explore Cas role in cellular function, we established Cas-deficient and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Cell Size
Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibronectins

Share to Molecular Weight

Share to Phosphotyrosine

Share to Retinoblastoma-Like Protein p130

Share to Wound Healing

Source

Identifiers

PMID: 10448062
DOI: 10.1006/bbrc.1999.1162

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p130(Cas), an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblasts.PMID 10448062Read ↗

Essential roles of Crk and CrkL in fibroblast structure and motility.Semantic proximity Read ↗

Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate.Semantic proximity Read ↗

Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix.Semantic proximity Read ↗

Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility.Semantic proximity Read ↗

Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the CytoskeletonSemantic proximity Read ↗

Inactivating Negative Regulators of Cortical Branched Actin Enhances Persistence of Single Cell MigrationSemantic proximity Read ↗

The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts.Semantic proximity Read ↗

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.Semantic proximity Read ↗

Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness.Semantic proximity Read ↗

A Novel Cas Family Member, HEPL, Regulates FAK and Cell SpreadingSemantic proximity Read ↗

Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth.Semantic proximity Read ↗

A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.