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Article

Csk, a critical link of g protein signals to actin cytoskeletal reorganization.

Developmental cell - 1 Jun 2002

Lowry William E, Huang Jianyun, Ma Yong-Chao, Ali Shariq, Wang Dongxia, Williams Daniel M, Okada Masato, Cole Philip A, Huang Xin-Yun

Abstract excerpt

Heterotrimeric G proteins can signal to reorganize the actin cytoskeleton, but the mechanism is unclear. Here we report that, in tyrosine kinase Csk-deficient mouse embryonic fibroblast cells, G protein (Gbetagamma, Galpha(12), Galpha(13), and Galpha(q))-induced, and G protein-coupled receptor-induced, actin stress fiber formation was completely blocked. Reintroduction of Csk into Csk-deficent cells restored the...

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PMID: 12062086
DOI: 10.1016/s1534-5807(02)00175-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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