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Article

C-terminal Src kinase controls development and maintenance of mouse squamous epithelia.

The EMBO journal - 7 Mar 2007

Yagi Reiko, Waguri Satoshi, Sumikawa Yasuyuki, Nada Shigeyuki, Oneyama Chitose, Itami Satoshi, Schmedt Christian, Uchiyama Yasuo, Okada Masato

Abstract excerpt

Carboxy-terminal Src kinase (Csk) is a negative regulator of Src family kinases, which play pivotal roles in controlling cell adhesion, migration, and cancer progression. To elucidate the in vivo role of Csk in epithelial tissues, we conditionally inactivated Csk in squamous epithelia using the keratin-5 promoter/Cre-loxP system in mice. The mutant mice developed apparent defects in the skin, esophagus, and...

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Identifiers

PMID: 17304209
DOI: 10.1038/sj.emboj.7601595
PMCID: PMC1817640

Genes

TNF
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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