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Article

Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate.

The Journal of biological chemistry - 26 Jul 2002

Huang Jinhong, Hamasaki Hiroko, Nakamoto Tetsuya, Honda Hiroaki, Hirai Hisamaru, Saito Masaki, Takato Tsuyoshi, Sakai Ryuichi

Abstract excerpt

The Crk-associated substrate (Cas) is a unique docking protein that possesses a repetitive stretch of tyrosine-containing motifs and an Src homology 3 (SH3) domain. Embryonic fibroblasts lacking Cas demonstrated resistance to Src-induced transformation along with impaired actin bundling and cell motility, indicating critical roles of Cas in actin cytoskeleton organization, cell migration, and oncogenesis. To gain...

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Identifiers

PMID: 12011056
DOI: 10.1074/jbc.M203063200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate.PMID 12011056Read ↗

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