Abl kinases regulate FGF signaling independent of Crk phosphorylation to prevent Peters anomaly

Abstract excerpt

Peters anomaly, the most common cause of congenital corneal opacity, stems from corneal-lenticular adhesion. Despite numerous identified mutations, a cohesive molecular framework of the disease’s etiology remains elusive. Here, we identified Abl kinases as pivotal regulators of FGF signaling, as genetic ablation of Abl kinases restores lens induction even in the absence of FGF signaling. Intriguingly, both Abl ki...

Topics

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• Cornea
• CSK Tyrosine-Protein Kinase
• Fluorescence Resonance Energy Transfer
• Mesoderm
• Myelin P0 Protein
• Neural Crest
• Retinoblastoma-Like Protein p130
• src-Family Kinases

Identifiers and source

Literature Corpus work

b168d52a-5210-5dd5-bccf-9c53f41eed6e

DOI

10.1101/2024.10.24.619064