Article
The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network.
Molecular and cellular biology - 1 Jul 2003
Bladt Friedhelm, Aippersbach Elke, Gelkop Sigal, Strasser Geraldine A, Nash Piers, Tafuri Anna, Gertler Frank B, Pawson Tony
Abstract excerpt
Mammalian Nck1 and Nck2 are closely related adaptor proteins that possess three SH3 domains, followed by an SH2 domain, and are implicated in coupling phosphotyrosine signals to polypeptides that regulate the actin cytoskeleton. However, the in vivo functions of Nck1 and Nck2 have not been defined. We have mutated the murine Nck1 and Nck2 genes and incorporated beta-galactosidase reporters into the mutant loci....
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