Article
Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice.
Cell - 18 Jun 1993
Imamoto A, Soriano P
Abstract excerpt
All Src family non-receptor tyrosine kinases are negatively regulated by phosphorylation at a carboxy-terminal tyrosine. To analyze the significance of this regulation during development, we have generated mice deficient in Csk, a kinase that phosphorylates this tyrosine, by gene targeting in emb...
Topics
- Animals
- Base Sequence
- CSK Tyrosine-Protein Kinase
- Cell Line
- Gene Expression Regulation
- Genes, Lethal
- Genes, src
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Neural Tube Defects
- Phenotype
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins pp60(c-src)
- src-Family Kinases