Article
Specific and redundant roles of Src and Fyn in organizing the cytoskeleton.
Nature - 20 Jul 1995
Thomas S M, Soriano P, Imamoto A
Abstract excerpt
Mouse embryos lacking Csk, a negative regulator of Src family kinases, exhibit defects in neurulation and die at mid-gestation. To determine the role of activated Src family kinases in the csk- phenotype, we have introduced mutations in the src and fyn genes into the csk- mutant background. Genetic analysis reveals that src, but not fyn, is partly epistatic to the csk gene. Biochemical analysis indicates that...
Topics
- Animals
- Base Sequence
- CSK Tyrosine-Protein Kinase
- Cell Adhesion Molecules
- Cell Line
- Cytoskeleton
- DNA Primers
- Embryonic and Fetal Development
- Enzyme Activation
- Mice
- Molecular Sequence Data