Article
Specific and redundant roles of Src and Fyn in organizing the cytoskeleton.
Nature - 20 Jul 1995
Thomas S M, Soriano P, Imamoto A
Abstract excerpt
Mouse embryos lacking Csk, a negative regulator of Src family kinases, exhibit defects in neurulation and die at mid-gestation. To determine the role of activated Src family kinases in the csk- phenotype, we have introduced mutations in the src and fyn genes into the csk- mutant background. Genetic analysis reveals that src, but not fyn, is partly epistatic to the csk gene. Biochemical analysis indicates that...
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