Article
IGF-I in epithelial ovarian cancer and its role in disease progression.
Growth factors (Chur, Switzerland) - 1 Oct 2007
Brokaw Jane, Katsaros Dionyssios, Wiley Andrew, Lu Lingeng, Su Dan, Sochirca Olga, de la Longrais Irene A Rigault, Mayne Susan, Risch Harvey, Yu Herbert
Abstract excerpt
Insulin-like growth factor-I (IGF-I) is known to be involved in the development and progression of several types of solid tumors including ovarian cancer. IGF-I levels in local tissue is subject to both endocrine and paracrine/autocrine regulation. To investigate which regulation is more importantly involved in IGF-I action in ovarian cancer regarding tumor progression, we analyzed IGF-I mRNA expression (assuming...
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