Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk.

doi:10.1093/hmg/ddr087

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk.

Human molecular genetics - 1 Jun 2011

Pearce Celeste Leigh, Doherty Jennifer A, Van Den Berg David J, Moysich Kirsten, Hsu Chris, Cushing-Haugen Kara L, Conti David V, Ramus Susan J, Gentry-Maharaj Aleksandra, Menon Usha, Gayther Simon A, Pharoah Paul D P, Song Honglin, Kjaer Susanne K, Hogdall Estrid, Hogdall Claus, Whittemore Alice S, McGuire Valerie, Sieh Weiva, Gronwald Jacek, Medrek Krzysztof, Jakubowska Anna, Lubinski Jan, Chenevix-Trench Georgia, Beesley Jonathan, Webb Penelope M, Berchuck Andrew, Schildkraut Joellen M, Iversen Edwin S, Moorman Patricia G, Edlund Christopher K, Stram Daniel O, Pike Malcolm C, Ness Roberta B, Rossing Mary Anne, Wu Anna H

Abstract excerpt

The insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. We hypothesized that genetic variation in this pathway may influence risk of ovarian cancer. A three-center study of non-Hispanic whites including 1880 control women, 1135 women with invasive epithelial ovarian cancer and 321 women with borderline epithelial ovarian tumors was carried out to test the association between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Ovarian Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Insulin-Like Growth Factor Binding Protein 1

Share to Insulin-Like Growth Factor Binding Protein 3

Share to Insulin-Like Growth Factor Binding Proteins

Share to Insulin-Like Growth Factor I

Share to Insulin-Like Growth Factor II

Share to Neoplasms, Glandular and Epithelial

Source

Open in PubMed Open full text

Identifiers

PMID: 21422097
DOI: 10.1093/hmg/ddr087
PMCID: PMC3090188

Genes

IGF2
IGF1
IGFBP1
IGFBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk.PMID 21422097Read ↗

Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk.Semantic proximity Read ↗

Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers.Semantic proximity Read ↗

A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers.Semantic proximity Read ↗

Interaction of insulin-like growth factor-I and insulin resistance-related genetic variants with lifestyle factors on postmenopausal breast cancer risk.Semantic proximity Read ↗

Genetic variants and traits related to insulin-like growth factor-I and insulin resistance and their interaction with lifestyles on postmenopausal colorectal cancer risk.Semantic proximity Read ↗

Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.Semantic proximity Read ↗

IGF2R missense single-nucleotide polymorphisms and breast cancer risk: the multiethnic cohort study.Semantic proximity Read ↗

Association of polymorphisms and haplotypes in the insulin-like growth factor 1 receptor (IGF1R) gene with the risk of breast cancer in Korean women.Semantic proximity Read ↗

Genetic variation in IGF2 and HTRA1 and breast cancer risk among BRCA1 and BRCA2 carriers.Semantic proximity Read ↗

Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians.Semantic proximity Read ↗

IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3).Semantic proximity Read ↗

Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.