Article
Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2010
Gu Fangyi, Schumacher Fredrick R, Canzian Federico, Allen Naomi E, Albanes Demetrius, Berg Christine D, Berndt Sonja I, Boeing Heiner, Bueno-de-Mesquita H Bas, Buring Julie E, Chabbert-Buffet Nathalie, Chanock Stephen J, Clavel-Chapelon Françoise, Dumeaux Vanessa, Gaziano J Michael, Giovannucci Edward L, Haiman Christopher A, Hankinson Susan E, Hayes Richard B, Henderson Brian E, Hunter David J, Hoover Robert N, Johansson Mattias, Key Timothy J, Khaw Kay-Tee, Kolonel Laurence N, Lagiou Pagona, Lee I-Min, LeMarchand Loic, Lund Eiliv, Ma Jing, Onland-Moret N Charlotte, Overvad Kim, Rodriguez Laudina, Sacerdote Carlotta, Sánchez Maria-José, Stampfer Meir J, Stattin Pär, Stram Daniel O, Thomas Gilles, Thun Michael J, Tjønneland Anne, Trichopoulos Dimitrios, Tumino Rosario, Virtamo Jarmo, Weinstein Stephanie J, Willett Walter C, Yeager Meredith, Zhang Shumin M, Kaaks Rudolf, Riboli Elio, Ziegler Regina G, Kraft Peter
Abstract excerpt
BACKGROUND: Circulating levels of insulin-like growth factor I (IGF-I) and its main binding protein, IGF binding protein 3 (IGFBP-3), have been associated with risk of several types of cancer. Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins. METHODS: We systematically examined common genetic variation in 18 genes in the IGF signaling pathway for associations...
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