Article
Polymorphic CA repeats in the IGF-I gene and breast cancer.
Breast cancer research and treatment - 1 Nov 2001
Yu H, Li B D, Smith M, Shi R, Berkel H J, Kato I
Abstract excerpt
Insulin-like growth factor (IGF)-I is a potent mitogen for breast cancer cells and may play a role in the disease. Although the involvement of IGF-I phenotype in breast cancer has been studied extensively, little is known about IGF-I genotype in relation to the disease. The IGF-I gene contains a polymorphic region composed of multiple cytosine-adenine dinucleotides (CA repeats). Studies of other genes indicate...
Topics
- Adult
- Aged
- Breast Neoplasms
- Dinucleotide Repeats
- Female
- Genotype
- Humans
- Insulin-Like Growth Factor I
- Middle Aged
- Polymorphism, Genetic