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Article

The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights

1 Feb 2007

Abstract excerpt

IGF-I receptor (IGF-IR) signaling and functions are mediated through the activities of a complex molecular network of positive (e.g., type I IGF) and negative (e.g., the type II IGF receptor, IGF-IIR) effectors. Under normal physiological conditions, the balance between the expression and activities of these molecules is tightly controlled. Changes in this delicate balance (e.g., overexpression of one effector)...

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PMID: 16931767
DOI: 10.1210/er.2006-0001

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