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Article

Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk.

Anais da Academia Brasileira de Ciencias - 1 Jan 2000

Costa-Silva Danylo R, Barros-Oliveira Maria DA Conceição, Borges Rafael S, Tavares Cléciton B, Borges Umbelina S, Alves-Ribeiro Francisco A, Silva Vladimir C, Silva Benedito B DA

Abstract excerpt

Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, acting synergistically with estrogen to increase neoplastic cell proliferation. This review aims to present the recent...

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PMID: 27925035
DOI: 10.1590/0001-3765201620160169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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