The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic Growth

Abstract excerpt

Several decades of basic and clinical research have demonstrated that there is an association between the insulin-like growth factors (IGFs) and neoplasia. We begin with a brief discussion of the function and regulation of expression of the IGFs, their receptors and the IGF-binding proteins (IGFBPs). A number of investigational interventional strategies targeting the GH or IGFs are then reviewed. Finally, we have...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer, Hypoxia, and Metabolism
• Share to Growth Hormone and Insulin-like Growth Factors
• Share to Metabolism, Diabetes, and Cancer