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The Role of the IGF System in Cancer: From Basic to Clinical Studies and Clinical Applications

1 Jan 2002

Abstract excerpt

Insulin-like growth factors (IGFs) are important mediators of growth, development, and survival, are synthesized by almost any tissue in the body, and their action is modulated by a complex network of molecules, including binding proteins, proteases and receptors, which all comprise the IGF system. Evidence from in vitro and animal studies suggests that overexpression of IGFs by cancer cells and/or the nearby...

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PMID: 12417786
DOI: 10.1159/000066230

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Source receipt: pubmed, retrieved 7 Sept 2026.

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