Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of tau aggregation in cell models of tauopathy.

Current Alzheimer research - 1 Dec 2007

Khlistunova Inna, Pickhardt Marcus, Biernat Jacek, Wang Yipeng, Mandelkow Eva-Maria, Mandelkow Eckhard

Abstract excerpt

The pathological aggregation of tau into paired helical filaments is a hallmark of several neurodegenerative diseases, including Alzheimer's disease. We have generated cell models of tau aggregation in order to study mechanisms involving abnormal changes of tau. In the cell models the repeat domain of tau (tau(RD)) and some of its variants are expressed in a regulated fashion, e.g. the 4-repeat domain of tau with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Biological

Share to Mutation

Share to tau Proteins

Share to Tauopathies

Share to Transfection

Source

Identifiers

PMID: 18220518
DOI: 10.2174/156720507783018307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of tau aggregation in cell models of tauopathy.PMID 18220518Read ↗

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs.Semantic proximity Read ↗

N-phenylamine derivatives as aggregation inhibitors in cell models of tauopathy.Semantic proximity Read ↗

Generation of tau aggregates and clearance by autophagy in an inducible cell model of tauopathy.Semantic proximity Read ↗

Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy.Semantic proximity Read ↗

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau FragmentSemantic proximity Read ↗

Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity.Semantic proximity Read ↗

Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of TauopathySemantic proximity Read ↗

Peptide-based inhibitors of Tau aggregation as a potential therapeutic for Alzheimer’s disease and other TauopathiesSemantic proximity Read ↗

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.Semantic proximity Read ↗

In vitro Tau Aggregation Inducer Molecules Influence the Effects of MAPT Mutations on Aggregation Dynamics.Semantic proximity Read ↗

<i>In vitro</i> tau aggregation inducer molecules influence the effects of <i>MAPT</i> mutations on aggregation dynamicsSemantic proximity Read ↗

A novel peptide‐based tau aggregation inhibitor as a potential therapeutic for Alzheimer's disease and other tauopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.