Article

<i>In vitro</i> tau aggregation inducer molecules influence the effects of <i>MAPT</i> mutations on aggregation dynamics

2021-08-06

Abstract excerpt

Alzheimer’s disease (AD) and Alzheimer’s disease related dementias (ADRDs) affect 6 million Americans and they are projected to have an estimated health care cost of $355 billion for 2021. A histopathological hallmark of AD and many ADRDs is the aberrant intracellular accumulation of the microtubule associated protein tau. These neurodegenerative disorders that contain tau aggregates are collectively known as tauo...

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Literature Corpus work: b447b611-008a-5d32-9aa3-3729e8cc9039
DOI: 10.1101/2021.08.06.455436

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