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Article

Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy

17 May 2018

Abstract excerpt

Neurofibrillary tangles composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases collectively termed tauopathy. To understand the mechanisms underlying the cause of tauopathy, precise cellular and animal models are required. Recent data suggest that the transient introduction of exogenous tau can accelerate the development of tauopathy in the...

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PMID: 29772786
DOI: 10.3390/ijms19051497

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