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Article

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs.

The Journal of biological chemistry - 13 Jan 2006

Khlistunova Inna, Biernat Jacek, Wang Yipeng, Pickhardt Marcus, von Bergen Martin, Gazova Zuzana, Mandelkow Eckhard, Mandelkow Eva-Maria

Abstract excerpt

We generated several cell models of tauopathy in order to study the mechanisms of neurodegeneration in diseases involving abnormal changes of tau protein. N2a neuroblastoma cell lines were created that inducibly express different variants of the repeat domain of tau (tau(RD)) when exposed to doxycycline (Tet-On system). The following three constructs were chosen: (i) the repeat domain of tau that coincides with...

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PMID: 16246844
DOI: 10.1074/jbc.M507753200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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