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Article

Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy.

Neurobiology of aging - 1 Sept 2017

Pickhardt Marcus, Biernat Jacek, Hübschmann Sabrina, Dennissen Frank J A, Timm Thomas, Aho Annukka, Mandelkow Eva-Maria, Mandelkow Eckhard

Abstract excerpt

The aggregation of Tau protein is a hallmark of neurodegenerative diseases including Alzheimer's disease. Previously, we generated a cell model of tauopathy based on the 4-repeat domain with the FTDP-17 mutation ΔK280 (Tau4RDΔK) which is expressed in a regulatable fashion (tet-on). The deletion variant ΔK280 is highly amyloidogenic and forms fibrous aggregates in neuroblastoma N2a cells staining with the reporter...

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PMID: 28600952
DOI: 10.1016/j.neurobiolaging.2017.04.022

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