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Article

In vitro Tau Aggregation Inducer Molecules Influence the Effects of MAPT Mutations on Aggregation Dynamics.

Biochemistry - 5 Jul 2022

Ingham David J, Hillyer Kelsey M, McGuire Madison J, Gamblin Truman C

Abstract excerpt

Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) affect 6 million Americans, and they are projected to have an estimated health care cost of $355 billion for 2021. A histopathological hallmark of AD and many ADRDs is the aberrant intracellular accumulation of the microtubule-associated protein tau. These neurodegenerative disorders that contain tau aggregates are collectively known as...

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Identifiers

PMID: 35731895
DOI: 10.1021/acs.biochem.2c00111
PMCID: PMC9260964

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In vitro Tau Aggregation Inducer Molecules Influence the Effects of MAPT Mutations on Aggregation Dynamics.PMID 35731895Read ↗

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