Article
N-phenylamine derivatives as aggregation inhibitors in cell models of tauopathy.
Current Alzheimer research - 1 Sept 2007
Pickhardt M, Biernat J, Khlistunova I, Wang Y-P, Gazova Z, Mandelkow E-M, Mandelkow E
Abstract excerpt
Cell models of tauopathy were generated in order to study mechanisms of neurodegeneration involving abnormal changes of tau. They are based on neuroblastoma cell lines (N2a) that inducibly express different forms of the repeat domain of tau (tau(RD)), e.g. the 4-repeat domain of tau with the wild-type sequence, the repeat domain with the DeltaK280 mutation ("pro-aggregation mutant"), or the repeat domain with...
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