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Article

Generation of tau aggregates and clearance by autophagy in an inducible cell model of tauopathy.

Neuro-degenerative diseases - 1 Jan 2010

Wang Y, Krüger U, Mandelkow E, Mandelkow E-M

Abstract excerpt

We have studied the mechanism of aggregation in an inducible cell model of Tau pathology. When the repeat domain of human Tau (Tau(RD)) carrying the FTDP-17 mutation DeltaK280 is expressed, the cells develop aggregates, as seen by thioflavin S fluorescence, electron microscopy, and sarkosyl extra...

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PMID: 20173337
DOI: 10.1159/000285516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20173337-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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