Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment

Abstract excerpt

Tau aggregation is a hallmark of a group of neurodegenerative diseases termed Tauopathies. Reduction of aggregation-prone Tau has emerged as a promising therapeutic approach. Here, we show that an anti-aggregant Tau fragment (F3 ΔKPP , residues 258–360) harboring the ΔK280 mutation and two proline substitutions (I 277 P & I 308 P) in the repeat domain can inhibit aggregation of Tau constructs in vitro, in...

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