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Article

Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity.

Journal of neuroscience research - 15 Nov 2010

Zhao Kelly, Ippolito Giulia, Wang Lulu, Price Valerie, Kim Mi Hwa, Cornwell Gavin, Fulenchek Stephanie, Breen Gail A, Goux Warren J, D'Mello Santosh R

Abstract excerpt

Intracellular aggregation of tau is a pathological hallmark in Alzheimer's disease and other tauopathies. The mechanisms underlying tau aggregation and the role that these aggregates play in neuronal death have remained controversial. To study these issues, we established a cell culture model of tauopathy using a hexameric peptide with the sequence (306)VQIVYK(311) located within the third microtubule-binding...

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PMID: 20882568
DOI: 10.1002/jnr.22485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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